Integumentary System
Chapter 5
Lymphatic vessels pick up leaked plasma fluid and proteins
from the dermis; lymphocytes in lymphoid organs and tissues
enhance the skin’s protective role by defending against specific
pathogens via the immune response
The skin’s keratinized epithelium provides a mechanical barrier
to pathogens; epithelial dendritic cells and dermal macrophages
act as antigen presenters in the immune response; acid pH of
skin secretions inhibits growth of bacteria on the skin
Skeletal System
Chapters 6–8
Lymphatic vessels pick up leaked plasma fluid and proteins from
the periostea; immune cells protect bones from pathogens
The bones house hematopoietic tissue which produces the
lymphocytes (and macrophages) that populate lymphoid organs
and provide immunity
Muscular System
Chapters 9–10
Lymphatic vessels pick up leaked fluids and proteins; immune
cells protect muscles from pathogens
The skeletal muscle “pump” aids the flow of lymph; shivering
produces heat at the beginning of a fever
S Y S T E M C O N N E C T I O N S
Homeostatic Interrelationships Between the
Lymphatic
System/Immunity
and Other Body Systems
Access more System Connections in the Study Area at
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Nervous System
Chapters 11–15
Lymphatic vessels pick up leaked plasma fluid and proteins
in PNS structures; immune cells protect PNS structures from
specific pathogens
The nervous system innervates larger lymphatics; opiate
neuropeptides influence immune functions; the brain helps
regulate immune response
Endocrine System
Chapter 16
Lymphatic vessels pick up leaked fluids and proteins; lymph helps
distribute hormones; immune cells protect endocrine organs
Stress hormones depress immune activity; the thymus produces
hormones and paracrines that are involved in the maturation of
T cells
Cardiovascular System
Chapters 17–19
Lymphatic vessels pick up leaked plasma and proteins; spleen
removes and destroys aged RBCs and debris, and stores iron
and platelets; immune cells protect cardiovascular organs from
specific pathogens
Blood is the source of lymph; lymphatics develop from veins;
blood circulates immune elements
Respiratory System
Chapter 22
Lymphatic vessels pick up leaked fluids and proteins from
respiratory organs; immune cells protect respiratory organs
from specific pathogens; the tonsils and plasma cells in the
respiratory mucosa (which secrete the antibody IgA) prevent
pathogen invasion
The lungs provide O
2
needed by lymphoid/immune cells and
eliminate CO
2
; the pharynx houses the tonsils; respiratory
“pump” aids lymph flow
Digestive System
Chapter 23
Lymphatic vessels pick up leaked fluids and proteins from
digestive organs; lymph transports some products of fat
digestion to the blood; lymphoid follicles in the intestinal wall
prevent invasion of pathogens
The digestive system digests and absorbs nutrients needed by
cells of lymphoid organs; gastric acidity inhibits pathogens’
entry into blood
Urinary System
Chapters 25–26
Lymphatic vessels pick up leaked fluid and proteins from urinary
organs; immune cells protect urinary organs from specific
pathogens
Urinary system eliminates wastes and maintains homeostatic
balances of water, pH, and electrolytes in the blood for
lymphoid/immune cell functioning; urine flushes some
pathogens out of the urinary tract
Reproductive System
Chapter 27
Lymphatic vessels pick up leaked fluid and proteins; immune
cells protect against pathogens
Reproductive organs’ hormones may influence immune
functioning; acidity of vaginal secretions is bacteriostatic
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